ZOOL.
252 EXAM QUESTIONS - LYMPHATIC AND IMMUNE
[1-9] [10-19] [20-29] [30-39] [40-49] [50-59] [60-69] [70-79] [80-89] [90-99] [100-109] [110-119] [120-129]
[BATCH 941]
[BATCH 972]
[BATCH 961]
[BATCH 931]
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BATCH 941
1-9
- When do most of the events of immunocompetency
development occur?
- fetal development
- childhood
- puberty
- ongoing process throughout life
- after retirement. Only then are you relaxed
enough for the immune system to function
properly. [top]
- Complement proteins:
- are a type of antibody.
- are a type of cytokine.
- are secreted by plasma cells.
- are secreted by some types of T cells.
- circulate in the plasma in an inactive form. [top]
- Identify the mechanism or mechanisms which aid in
increasing venous flow of blood and lymphatic system flow
of lymph.
- skeletal muscle pumping
- respiratory pumping
- one-way valves
- a and c
- all of the above [top]
Match each of the following
organs to the substance that it filters.
- air, food and
mucus
- lymph
- blood
|
- spleen
- tonsils
- lymph node [top]
|
- Which of the following
is not a function of the major histocompatibility
complex (MHC) Class I protein?
- presents
antigens from bacteria infecting a body cell to T
cells to stimulate a specific immune system
response
- presents
antigens from viruses infecting a body cell to T
cells to stimulate a specific immune system
response
- presents
antigens from proteins produced in a cancerous
cell to T cells to stimulate a specific immune
system response
- presents
antigens from cancer or foreign microorganisms to
identify infected cells to cytotoxic T cells
- presents
antigens from phagocytosed microorganisms to both
B and T cells to stimulate specific immune system
responses [top]
- How is active humoral
immunity usually initiated?
- A macrophage
phagocytoses a foreign substance and digests it;
the macrophage then presents antigens from the
foreign substance to a helper T cell (along with
secreting interleukin 1) which secretes cytokines
to stimulate B cell activation and division.
- B cells in a
lymph node bind to an antigen on a foreign
substance; the B cells present the antigen to a
helper T cell. Cytokines from the activated
helper T cell stimulate B cell division.
- Infected body
cells activate cytotoxic T cells to divide.
- a and b.
- all of the
above [top]
- Which of the following phrases best defines
agglutination?
- Attachment of antibodies to specific proteins on
the membranes of cells such that long chains of
cells and antibodies are formed that precipitate
from a solution.
- Polymerization of long strands of fibrin from
fibrinogen due to the actions of thrombin.
- Polymerization of long strands of fibrin from
fibrinogen due to the actions of thromboplastin.
- Groups of red blood cells and platelets trapped
within fibrin strands.
- A horrible allergic reaction to gluten. [top] [1-9]
10-19
- Which cell type coordinates immune responses by
activating and enhancing the activity of T cells, B cells
and phagocytic cells?
- helper T cells
- cytotoxic T cells
- suppressor T cells
- plasma cells
- memory B cells [top]
- Which class of immunoglobulin is found in the largest
concentration in circulation in the plasma?
- IgA
- IgD
- IgE
- IgG
- IgM [top]
- Which of the following proteins is the common step (point
of convergence) for complement activation and its results
whether stimulated by the antibody or bacterial
polysaccharides, whether it results in opsonization and
phagocytosis or formation of the membrane attack complex?
- C1
- C2
- C3
- C4
- C5 [top]
- How is active humoral immunity usually initiated?
- A macrophage phagocytoses a foreign substance and
digests it; the macrophage then presents antigens
from the foreign substance to a helper T cell
(along with secreting interleukin 1). The helper
T cell then binds to the appropriate B cell and
secretes cytokines to co-stimulate B cell
activation and division.
- B cells in a lymph node bind to an antigen on a
foreign substance; the B cells present the
antigen to a cytotoxic T cell. Cytokines from the
activated cytotoxic T cell stimulate B cell
division.
- Infected body cells activate helper T cells to
divide.
- a and b.
- all of the above [top]
- The only T cell population that can directly attack and
kill cells are the:
- cytotoxic cells.
- helper cells.
- suppressor cells.
- plasma cells. [top]
Match each of the following organs to the substance that it
filters.
- spleen
- tonsils
- lymph node
|
- air, food and mucus
- lymph
- blood [top]
|
Match each of the following lymphocytes with its function.
- helper T cells
- cytotoxic T cells
- suppressor T cells
- plasma cells
- memory B cells
|
- turns off the immune response
- coordinates immune responses by activating and
enhancing the activity of T cells, B cells and
phagocytic cells
- produces antibodies
- kills infected body cells
- divides to produce new antibody producing cells
during a secondary immune response [top]
[10-19]
|
Match the immunoglobulins to their function.
- IgA
- IgD
- IgE
- IgG
- IgM
|
- first antibody released during primary immune
responses
- found in the largest concentration in the plasma
- functions as the antigen receptor for a B cell
- found on surface of mast cells in the respiratory
and gastrointestinal tracts
- found in bodily secretions such as saliva, sweat,
intestinal juices and milk. [top]
|
- The lymph from the lower body is returned to the
cardiovascular system at the artery via the . (Pick the
pair of words which best fills in the blanks.)
- right subclavian vein -- right thoracic duct
- left subclavian vein -- left thoracic duct
- inferior vena cava -- cisterna chyli
- right subclavian vein -- left thoracic duct
- left subclavian vein-- right thoracic duct [top]
- Which of the following cells are fixed macrophages?
- Kupffer cells
- monocytes
- neutrophils
- basophils
- natural killer cells [top]
[20-29]
30-39
- Which of the following proteins is the common step (point
of convergence) for complement activation and its results
whether stimulated by the antibody or bacterial
polysaccharides, whether it results in opsonization and
phagocytosis or formation of the membrane attack complex?
- C1
- C2
- C3
- C4
- C5 [top]
- Which of the following would not really qualify as a
nonspecific defense mechanism?
- acidity of sweat, gastric and vaginal secretions
- antibody binding to a bacteria and activating
complement formation
- the mucus and cilia lining the respiratory tract
- the inflammatory response
- fever [top]
- When Joe was a young college student with no debts and a
strong back, he worked his way around the world. During
the course of his time abroad, he went to Turkey where
all visitors are required to be immunized for
tuberculosis. Joe's backpack with all his immunization
records was stolen somewhere around Istanbul, and he
tried pretty successfully to forget about ever having
been in Turkey. Ten years later after 150 unsuccessful
job applications, Joe applied to work at the Extra
Healthy Health Corporation and was administered a TB skin
test during the course of the physical administered to
all new workers. Joe's TB test was undeniably positive.
Despite a clean chest x-ray, the doctors at the Extra
Healthy Health Corporation were adamant that Joe should
take a year long course of intensive antibiotics despite
the fact that these antibiotics are very rough on the
liver and Joe's tests reveal that his liver is not in
wonderful shape (he felt it his duty to sample all local
alcoholic concoctions during his travels). You have known
Joe since long before he was a young college student. You
DO remember that Joe went to Turkey and had a TB
vaccination. Joe has come to you for advice. What should
you tell him?
- "Joe, TB can kill you. If Larry Hagman can
get a new liver, so can you. Take the
antibiotics."
- "Beats me how you got TB. Hope it's not that
antibiotic resistant kind. By the way, my kids
won't be visiting your kids for the next
year."
- "You wimp! Are you going to let those
knucklehead doctors run your life just because of
a little bitty inflamed spot? Don't take
antibiotics unless you are coughing up
blood."
- "Joe, didn't you have to get a TB
vaccination when you went into Turkey on that
crazy trip around the world? Why don't you see if
you can get a duplicate record of the
immunization and see if the Extra Healthy Health
people would settle for an annual chest x-ray to
check for TB?"
- "Well, Joe if I were you, I'd be sure my
will was up to date and that the premiums were
paid up on my life insurance policy. After all,
whether or not you have TB, you really need this
job so it looks like poverty and TB, or a few
paychecks before liver failure from the
antibiotics. Stress, TB or liver failure is bound
to kill you." [top]
- What type of cell is always infected by the human
immunodeficiency virus (HIV) once a person is infected?
- B cells
- natural killer cells
- cytotoxic T cells, CD8 cells
- helper T cells, CD4 cells
- neurons in the brain [top]
- Which of the following is not a function of the
major histocompatibility complex (MHC) Class I
protein?
- presents antigens from bacteria infecting a body
cell to T cells to stimulate a specific immune
system response
- presents antigens from viruses infecting a body
cell to T cells to stimulate a specific immune
system response
- presents antigens from proteins produced in a
cancerous cell to T cells and natural killer
cells to stimulate an immune system response
- presents antigens from cancer or foreign
microorganisms to identify infected cells to
cytotoxic T cells
- presents antigens from phagocytosed
microorganisms to both B and T cells to stimulate
specific immune system responses [top]
- How is active humoral immunity usually initiated?
- A macrophage phagocytoses a foreign substance and
digests it; the macrophage then presents antigens
from the foreign substance to a helper T cell
(along with secreting interleukin 1). The helper
T cell then binds to the appropriate B cell and
secretes cytokines to co-stimulate B cell
activation and division.
- B cells in a lymph node bind to an antigen on a
foreign substance; the B cells present the
antigen to a cytotoxic T cell. Cytokines from the
activated cytotoxic T cell stimulate B cell
division.
- Infected body cells activate helper T cells to
divide.
- a and b.
- all of the above [top]
- Costimulation is
- the binding of an antigen to a T or B cell to
activate that clone.
- the binding of a cytokine to its receptor on a T
or B cell to activate that clone.
- the binding of an antigen to a T or B cell
accompanied by the binding of a cytokine to its
receptor on the same T or B cell to activate that
clone.
- the binding of interleukin-1 to receptors of
cells is the hypothalamus to initiate a fever to
aid the function of the antibodies secreted by
plasma cells and the cytokines secreted by helper
T cells during a specific immune system response.
- the binding of cytokines from a helper T cell to
their receptors on macrophages, microphages and
natural killer cells to enhance their response to
an infection. [top]
- In clonal selection of B cells, which substance is
responsible for determining which cells will eventually
become cloned?
- antibody
- lymphocyte
- antigen
- macrophage
- Cloning of any form/type is not a phenomenon
which happens in nature. [top]
- The only T cell population that can directly attack and
kill cells are the:
- cytotoxic cells.
- helper cells.
- suppressor cells.
- plasma cells. [top]
- A single exposure to an antigen can lead to , but regular
repeated exposures to an antigen can lead to . Choose the
answer which best fills in the blanks in the preceeding
statement.
- anaphalaxis -- sensitization
- anaphalaxis -- tolerance
- tolerance -- anaphalaxis
- tolerance -- sensitization
- sensitization -- tolerance [top]
[30-39]
40-49
- List at least three ways that the immune system can
"kill" a cell and identify the type of cell
typically killed by that mechanism. [top]
- Explain the difference between the interleukins and the
interferons. [top]
- Briefly explain what happens in a lymph node, i.e. what
is the function of a lymph node. Your answer should
include specific cell types and a description of their
activities while in the node. [top]
- How does the binding of an antibody kill or neutralize a
pathogen? [top]
- Name at least 5 functions of the liver. (No
need to elaborate) [top]
BATCH 972
- Lymphatic capillaries found in the
intestinal villi that are important to lipid absorption
are termed:
- intestinal glands
- lacteals
- duodenal glands
- chyme
- none of the above. [top]
- Explain why Helper T cells are important
to the proper functioning of our immune system.
- The path of lymph flow from a lymphatic
capillary in the leg to the left subclavian vein would
include which of the following;
- vessels, duct, trunk
- trunk, duct, vessels
- duct, trunk, vessels
- vessels, trunk and duct
- none of the above. [top]
- The sac-like initial portion of the
thoracic duct that receives lymph from the legs and the
intestinal tract is the:
- lacteal
- right lymphatic duct
- cisterna chyli
- lymph vessel
- none of the above. [top]
- The lymphoid organ that is unique because
its underlying structure is not based on reticular
connective tissue is the:
- thymus
- spleen,
- lymph node
- tonsil
- none of the above. [top] [40-49]
50-59
- The lymphoid cells that serve as the
foundation of our humoral immune system are the:
- cytotoxic T cells
- helper T cells
- suppressor T cells
- B cells
- none of the above. [top]
- The lymphoid organ important to overall
function of both the immune system and the hematopoietic
system is the:
- thymus
- spleen
- lymph node
- tonsil
- none of the above. [top]
- The major lymphatic organ that has more
afferent than efferent vessels and serves a primary role
in lymph filtration would be the:
- thymus
- lymph node
- spleen
- palatine tonsils
- none of the above [top]
- Which of the following would not be
considered to be part of the nonspecific body defense
system?
- complement
- inflammation
- immunoglobulins
- fever
- none of the above [top]
- The process by which neutrophils squeeze
through capillary walls in response to inflammatory
signals is termed:
- chemotaxis
- diapedesis
- margination
- opsonization
- none of the above [top]
- Small molecules that are not immunogenic
by themselves but can be very immunogenic when combined
with larger proteins are termed:
- haptens
- complete antigens
- bugs
- agglutinins
- none of the above [top]
- Which of the following might be involved
in B-cell activation?
- antigens
- helper T-cells
- lymphokines
- all of the above
- none of the above [top]
- Although all of the following cells are
involved in nonspecific cellular defenses, the one that
is not phagocytic is the:
- natural killer or NK cells
- monocytes
- macrophages
- neutrophils
- none of the above [top]
- Which of the following is not associated
with the general inflammatory response?
- vasodilation
- increased capillary permeability
- inflammatory mediator release
- phagocyte mobilization
- none of the above [top]
- The direct killing of microorganisms,
enhancement of the inflammatory response and augmentation
of phagocytosis by opsonization would best characterize
which system?
- interferon
- complement
- natural killer cell
- defensin
- none of the above [top] [50-59]
60-69
- Substances released by leukocytes and
macrophages that stimulate the hypothalamus to increase
body temperature are:
- antigens
- haptens
- pyrogens
- kinins
- none of the above [top]
- Which of the following are characteristic
of the specific body defense or immune system?
- memory for previously exposed
antigens
- is antigen specific
- involves a systemic response
- all of the above
- none of the above [top]
- The class of antibody that is considered
to be the "secondary response Ab", is found in
highest concentration in plasma and has a complement
binding site (can fix complement) would be:
- IgM
- IgG
- IgA,
- IgD
- IgE [top]
- The class of antibody found on the surface
of mast cells and basophils that plays a leading role in
immediate hypersensitivity reaction s would be:
- IgM
- IgG
- IgA
- IgD
- IgE [top]
- In terms of antigen recognition, the major
difference between B lymphocytes and T lymphocytes is:
- T lymphocytes originate in the
bone marrow
- T lymphocytes only respond to
"presented" antigens
- immunocompetent T lymphocytes can
be found in both blood and lymph
- all of the above
- none of the above [top]
- In general, the effect of vaccine
administration is to provide:
- active humoral immunity
- passive humoral immunity
- active cell mediated immunity
- passive cell mediated immunity
- none of the above [top]
- When considered together, the variable
regions of the heavy and light chains of an antibody
molecule represent the:
- antigen binding site
- complement binding site
- stem region
- macrophage binding site
- none of the above [top]
Define each of the following:
- Perforin - [top]
- Cytokines - [top]
- Major histocompatability complex (MHC) - [top] [60-69]
70-79
- Sketch and label a typical antibody
molecule and explain how antibodies mediate humoral
immunity. [top]
- Explain why Helper T cells are so
important to the proper functioning of our immune system.
[top]
BATCH 961
Match the following:
- spleen
- lymph nodes
- thymus
- peyers patches
- tonsils
|
- important in removing
infectious agents that enter in food
- filters lymph fluid
- produces thymosin
- does not directly fight
infectious agents
- contains crypts that trap
bacteria
- is made of a specialized
epithelial cell
- removes old red blood cells
- important maturation site for
T lymphocytes
- contains white pulp and red
pulp [top]
|
- The immune system is also called the
- nonspecific defense system
- the innate defense system
- specific defense system
- inflammation [top]
- Acidity of the skin, an unbroken
epithelial lining, digestive enzymes, sticky mucous, and
iron chelators are part of the ...
- phagocytes
- inflammation
- chemical defenses
- surface membrane barrier [top]
- Which of the following is required for
the alternative pathway of complement activation
- antibody free of antigen
- antibody bound to its antigen
- polysaccharide molecules found
on the surface of some bacteria [top] [70-79]
80-89
- What are the chemicals released from
the macrophages that induce fever
- antibodies
- complement
- interferons
- haptens
- pyrogens [top]
- The presence of this protein bound to
an antibody enables the antibody to kill a foreign cell
- hapten
- lymphotoxin
- perforin
- complement [top]
- Humoral immunity is the type of
immunity that involves...
- phagocytes
- pyrogens
- antibodies
- cytotoxic T cells [top]
- Which of the following chemical can be
best described as being involved in blocking the spread
of viral infection?
- interferon
- pyrogens
- complement
- tumor necrosis factor [top]
- Which cells of the body defenses have
as their major function the production of antibodies
- macrophages
- suppressor T cells
- B lymphocytes
- plasma cells
- all of the above [top]
- Why is the secondary immune response
much better at fighting infection
- get more antibodies and faster
- the antibodies are better at
binding to antigen
- antibody levels stay high for
longer
- all are correct
- none are correct [top]
- Of the mechanisms by which antibodies
help the immune system defeat infection, which one deals
with the binding of antibody to a soluble antigen causing
it to fall out of solution?
- complement fixation
- neutralization
- precipitation
- agglutination [top]
- Which of the following is a
requirement to initiate a cell mediated immune response
- cytotoxic T cells
- suppressor T cells
- helper T cells [top]
- Which of the following chemicals will
fragment DNA?
- lymphotoxin
- perforin
- tumor necrosis factor
- gamma interferon [top] [80-89]
90-99
- Which of the following is
not a part of the nonspecific cellular immunity?
- natural killer cells
- macrophages
- neutraphils
- eosinophils
- plasma cells [top]
- What is the advantage of getting a
fever when you have an bacterial infection? [top]
- Why are iron chelators part of our
nonspecific body defenses? [top]
- Which of the following is not true
about lymphatic vessels.
- they contain valves to prevent
back flow of fluid
- they transport blood, which as
escaped the capillaries, back to the
cardiovascular system
- lymphatic capillaries are more
permeable then blood capillaries
- they contain endothelial cells
[top]
- Lymphatic vessels are absent from the
- lungs
- central nervous system
- muscle
- organs of the digestive system
[top]
- The lymphatic fluid from the right leg
is ultimately drained by the
- thoracic duct
- right lymphatic duct
- left lymphatic duct
- superior thoracic duct [top]
- Which of the following chemicals are
released from cells infected by a virus?
- lymphotoxin
- perforin
- tumor necrosis factor
- gamma interferon [top]
- Type II alveolar cells or pneumocytes produce surfactant
which has a direct role in lowering...
- recoil
- elasticity
- compliance
- surface tension[top]
BATCH 931
- Which two systems would not
function properly without the lymphatic system?
- urinary and immune
- digestive and
cardiovascular
- respiratory and
immune
- cardiovascular and
immune
- respiratory and
cardiovascular [top]
- What is true of all
lymphoid organs?
- contain lymphocytes
and macrophages
- filter lymph
- filter blood
- produce antibodies
- produce complement
proteins [top]
[90-99]
100-109
- The tonsils that inhibit
pathogens from entering your auditory structures are the:
- palatine
- tubal
- pharyngeal
- adenoids
- lingual [top]
- The chemical secreted by
virus-infected cells to protect nearby cells from viruses
is:
- interferon
- complement
- antibodies
- cytokines
- perforin [top]
- A babys immune cells
consist of only cells whose antigen receptors did what
during fetal development?
- bound to fetal
molecules
- failed to bind to
fetal molecules[top]
- Receptor molecules that bind
to specific antigens are located on:
- all leukocytes
- b blood cells
- all phagocytes
- lymphocytes and
macrophages only
- lymphocytes only [top]
- What ultimately is most
important in determining which antigens can trigger
your immune response?
- your genes
- chemical
characteristics of the antigen
- whether or not
youve ever been exposed to that antigen
- how that antigen
infected you
- the size of your
memory cell population [top]
- In order for your TC
cells to respond to cancer cells (which are
mutated self cells), the cancer cells must:
- be infected with a
virus
- bear molecules
interpreted as foreign
- secrete cytokines
- be mitotic
- remain in lymph
nodes [top]
- Suppose you visit another
planet and are exposed to life forms and molecules that
you have never encountered before, including the organic
macromolecule Antigen Z. Antigen Z triggers an
immune response, and is eliminated mostly by your humoral
defenses. This would suggest that most Antigen Z
molecules:
- must appear in your
own cells membranes
- do not
necessarily appear in your own cells
membranes
- can "hide"
within your cells
- somehow disable your
T lymphocytes
- somehow disable your
B lymphocytes [top]
- Antigen Z is found on the
integument of the tiny blibbert worm, which entered your
nasal passages as you slept. Which immunoglobulin would
be most effective in preventing additional
blibbert worms from infecting you?
- IgM
- IgG
- IgA
- IgD
- IgE [top]
- Antigen Z is a toxin that
permanently disables the production of memory immune
cells. This would impair your:
- humoral immunity
- cellular immunity
- complement action
- immunoglobulin
action
- response to
subsequent infection by that Ag [top]
- Complement proteins
are most similar (in what they do to cells) to:
- cytokines
- clotting proteins
- albumin
- perforin
- immunoglobulins [top] [50-59] [100-109]
110-119
- Why would a mans
immune cells determine (falsely) that his own sperm are
foreign?
- sperm are first
formed during the time immunocompetency is
developing
- sperm are not
present during development of immunocompetency
- sperm antigens are
similar to those on normal gut bacteria [top]
- When do most of the events
of immunocompetency development occur?
- fetal development
- childhood
- puberty
- ongoing process
throughout life[top]
- The initiating protein in
the complement cascade binds
("fixes") to:
- self molecules
- antigens
- variable region of
the antibody
- constant region of
the antibody
- perforin [top]
- Describe the leukocytes,
including which type is most numerous, least numerous,
largest, differences in staining characteristics,
differences in organelles, and of course differences in
function. [top]
- Explain the following
(well-labeled, accurate diagrams will be sufficient):
- the structure of
antigen receptors on immune cells
- the structure of
antibodies, including chemical structure, and
names and functions of specific regions on an
antibody molecule
- list the
immunoglobulin classes, explain which general
region of the molecule differs in structure from
class to class, and one distinguishing
characteristic of each [top]
- A person with type O
blood:
- has RBCs that bear
the O antigen
- has anti-O antibody
circulating in the plasma
- can receive blood
transfusions from donors of any blood type
- is most likely to be
RH-
- lacks antigens of
the ABO class[top]
- Describe hemolytic
disease of the newborn. Your answer should include
the following - what causes jaundice? is there is
difference in risk depending on birth order? do both rh+
and rh- mothers need to be equally concerned? do ABO
incompatibilities matter at all? [top]
- The lymphatic system is
necessary because:
- osmotic pressure is higher
than hydrostatic pressure in the capillary beds
- hydrostatic pressure is higher
than osmotic pressure in the capillary beds
- capillaries do not allow water
to diffuse into the blood
- the presence of albumin
reduces the inward diffusion of water into the
blood
- all blood must be filtered [top]
- TRUE or FALSE: all lymphoid organs
filter lymph
- TRUE
- FALSE [top]
- Lymph nodes contain:
- B & T lymphocytes only
- B & T lymphocytes and
macrophages
- macrophages only
- B lymphocytes and macrophages
only
- T lymphocytes and macrophages
only [top] [110-119]
120-129
- What do the immune and endocrine
systems have in common?
- both regulate cells through
secreted chemicals
- both involve specific binding
of molecules to membrane receptor molecules
- both are classified as organ
systems
- a & b
- b & c [top]
- What ultimately determines
whether or not a particular antigen will trigger an
immune response?
- how potentially harmful the
antigen is
- prior exposure to or infection
with that antigen
- the genes of the infected
individual
- how the antigen enters the
body [top]
- What do perforin and complement
proteins have in common?
- both tear holes in pathogens
or infected/altered self cells
- both are considered to be
non-specific defenses
- both are associated primarily
with the humoral defenses
- both are associated primarily
with cell-mediated defenses
- both specialize in elimination
of bacteria [top]
- The cell-mediated immune system
specializes in eliminating:
- all pathogens
- bacteria
- viruses
- worms
- altered self cells [top]
- Which is the best definition of antigen?
- bacteria
- virus
- any foreign molecule
- a molecule that triggers an
immune response
- a disease-causing organism [top]
- What must be matched closely to result
in a successful organ transplant operation?
- organ size
- organ color
- blood type only
- MHC molecules on the cells of
the donor and recipient organs
- race of the donor and
recipient [top]
- A fetus with blood type B- inside a
mother with blood type B+:
- is at risk for HDN
- is not at risk for HDN [top] [120-129]